Clarkson researchers team hopes to unveil new signaling pathway
POTSDAM -- Clarkson University researchers from the Biochemistry and Proteomics Laboratory, led by Prof. Costel Darie, have had a manuscript accepted for publication in the Journal of Biological Chemistry.
The study investigated the receptor of a new pituitary hormone (Tumor Differentiation Factor, TDF) with differentiation activity on breast and prostate cancer cells. Based on their study, the TDF activates a possible novel pathway.The hope is to ultimately unveil how this new hormone works. The researchers believe that TDF has anti-cancer activity and potential as a future treatment.
The study is a combination of unique sets of expertise, from protein chemistry and proteomics, to analytical biochemistry, cell biology and neuroscience -- a new direction for Clarkson.
It was performed in Darie’s lab in the Department of Chemistry & Biomolecular Science with support from Mary Ann Gawinowicz’s Protein Chemistry core facility at Columbia University.
Most of the work was performed by Izabela Sokolowska, a Ph.D. student in Darie’s lab.